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Coming Soon	We formally characterized IgG and IgM seroconversion times, detection probabilities over time and antibody level kinetics using methods tailored to accommodate the diverse ways in which data have been collected and reported. Programs All Programs. Customer Controversies. Studies were conducted to investigate the mechanisms by which natural IgM antibodies act together with the alternative complement pathway to promote opsonization and adherence of encapsulated Bacteroides thetaiotaomicron and Bacteroides fragilis to polymorphonuclear leukocytes PMN. Less clear. International License Manager.
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Michael Holers , Joshua M. Thurman; Female but Not Male Mice Deficient in Soluble IgM Are Susceptible to Chemically Induced Glomerular Injury.

J Immunol 15 October ; 8 : — B cell—targeted therapies are effective for treating multiple different kidney diseases in humans and also protect mice from Adriamycin nephropathy.

The absence of soluble IgM did not reduce glomerular complement activation, and IgG was seen deposited within the injured glomeruli. These findings indicate that natural IgM may prevent generation of autoreactive IgG. Circulating levels of anti-cardiolipin IgG decreased after induction of kidney injury in female mice, consistent with deposition of the Abs in injured tissues.

Better understanding of the mechanisms by which the immune system modulates and amplifies kidney injury may enable the development of targeted therapies to slow kidney disease progression. Sign In or Create an Account.

Search Dropdown Menu. header search search input Search input auto suggest. filter your search All Content The Journal of Immunology. Advanced Search. User Tools Dropdown. Sign In. Toggle Menu Menu Articles Current Issue Next in The JI Archive Brief Reviews Translating Immunology Pillars of Immunology COVID, SARS, and MERS Articles Monkeypox and Other Poxvirus Articles Annual Meeting Abstracts About the JI About the JI Journal Policies Alerts Authors Submit Instructions for Authors Journal Policies Editors The JI Editorial Board ImmunoHorizons Subscriptions Subscribe Members Librarians New Site FAQ.

Skip Nav Destination Close navigation menu Article navigation. Volume , Issue 8. Previous Article Next Article. Article Navigation. Research Article September 08 Female but Not Male Mice Deficient in Soluble IgM Are Susceptible to Chemically Induced Glomerular Injury Russell Whelan ; Russell Whelan.

This Site. Google Scholar. Andrew Feemster ; Andrew Feemster. Jennifer Laskowski ; Jennifer Laskowski. Brandon Renner ; Brandon Renner. Liudmila Kulik ; Liudmila Kulik. Felix Poppelaars ; Felix Poppelaars. Cameron Lee ; Cameron Lee. Michael Holers ; V. Michael Holers. Joshua M. Thurman Address correspondence and reprint requests to Dr.

Thurman, Division of Nephrology and Hypertension, C, East 19th Avenue, Aurora, CO

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